In Study 2, eight males (25 +/- 6 yrs) followed the same study design and testing procedure as for Study 1. Urine was collected prior to ingestion and at 3, 6, 9, and 12 h for the measurement of urinary HMB. Additional blood samples were obtained at 6, 9, and 12 hr. Blood samples were obtained prior to ingestion of treatment and at 30, 60, 90, 120, 150, and 180 min for the measurement of plasma HMB. In Study 1, eight males (32 +/- 10 yrs) participated in two randomize trials: 1) oral ingestion of 1g of HMB with water in capsule form (HMB), and 2) placebo. The aim of this investigation was to determine the time course kinetics of HMB and to determine whether oral glucose ingestion alters the kinetics. The dietary supplement, beta-hydroxy-beta-methylbutyrate (HMB), has been shown to decrease muscle proteolysis during the stress of exercise and disease.
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